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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
VRE: vancomycin resistant enterococci |
| Language |
J |
| AuthorList |
Haruyoshi Tomita1,2), Takahiro Nomura1), Jun Kurushima1), Koichi Tanimoto2) |
| Affiliation |
1) Department of Bacteriology, Gunma University, Graduate School of Medicine
2) Laboratory of Bacterial Drug Resistance, Gunma University, Graduate School of Medicine |
| Publication |
J.J.C.M.: 24 (3), 180-194, 2014 |
| Received |
July 31, 2014 |
| Accepted |
|
| Abstract |
The clinical significance of the Gram-positive bacteria Enterococcus spp. is related to the antibiotic resistances contributing to the risk of colonization and infection for human. The vancomycin (glycopeptide) resistant E. faecalis and E. faecium (VRE) are the greatest clinical importance and are the main causative species occurring nosocomial enterococci infections in the advanced countries. In Japan, the incidence of VRE infections are gradually increasing, and VRE became a serious problem in the medical facilities. This review describes the bacteriological features of enterococci, the genetic and molecular mechanisms of glycopeptide resistance, the epidemiology of VRE in Japan, the mobile conjugative plasmids enable facile transfer and spread of antibiotic resistance genes among enterococci, the methodology for VRE-detection, and the clinical control of VRE infections. The data obtained from our studies on the VRE isolates from human and animals (environments) are also shown. |
| Keywords |
VRE |
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