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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Study on antimicrobial susceptibilities of Salmonella enterica subsp. enterica serovar Typhi and Salmonella enterica subsp. enterica serovar Paratyphi A for three years |
| Language |
J |
| AuthorList |
Koji Yamada1), Kazuhisa Mezaki1), Maki Nagamatsu2,3), Norio Ohmagari2) |
| Affiliation |
1) Department of Clinical Laboratory, National Center for Global Health and Medicine
2) Disease Control and Prevention Center, National Center for Global Health and Medicine
3) Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine |
| Publication |
J.J.C.M.: 25 (2), 92-98, 2015 |
| Received |
June 2, 2014 |
| Accepted |
October 2, 2014 |
| Abstract |
The increase of Salmonella spp. with decreased susceptibility to fluoroquinolone become a clinical concern. The breakpoints for Salmonella enterica subsp. enterica serovar Typhi and extraintestinal salmonella were lowered in CLSI M100-S23. We analyzed the Salmonella Typhi and Salmonella enterica subsp. enterica serovar Paratyphi A which were isolated in our hospital from September, 2010 to August, 2013. All ten (71.4%, 10/14) isolates which were susceptible to fluoroquinolones and nalidixic acid (NA) resistant by CLSI M100-S19 criteria were intermediate or resistant to fluoroquinolones by CLSI M100-S23 criteria. Among three isolates (21.4%, 3/14) which were sensitive to NA, there is one isolate which was intermediate to levofloxacin. All isolates which were sensitive to NA were isolated from returned travelers from Cambodia, and isolates resistant to NA were isolated from returned travelers from south Asia including India. Among returned travelers to India, S. Typhi highly resistant to fluoroquinolones as well as ESBL producing S. Paratyphi A were isolated. It is important to select appropriate antibiotics based on areas where it was acquired for the treatment of typhoidal diseases. After the introduction of revised breakpoint, identification of isolates with decreased susceptibility to fluoroquinolone seems more accurate and feasible according to the findings in this study. |
| Keywords |
Salmonella enterica subsp. enterica serovar Typhi, Salmonella enterica subsp. enterica serovar Paratyphi A, CLSI M100-S23 |
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