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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Study of The Difference by Susceptibility Testing Methods of Vancomycin MIC values for Methicillin-Resistant Staphylococcus aureus and It's Clinical Significance |
| Language |
J |
| AuthorList |
Tomokazu Kuchibiro1), Issei Hirai2), Katsuyuki Houdai1), Kazushige Sakano3), Hironobu Yamaga4) |
| Affiliation |
1) Department of Clinical Laboratory, Naga Municipal Hospital
2) Department of Breast and General Thoracic Surgery, Naga Municipal Hospital
3) Department of Pharmacy, Naga Municipal Hospital
4) Department of Pediatrics, Naga Municipal Hospital |
| Publication |
J.J.C.M.: 25 (2), 131-137, 2015 |
| Received |
May 29, 2014 |
| Accepted |
October 24, 2014 |
| Abstract |
We evaluated three susceptibility testing methods for the vancomycin (VCM) MIC value of Methicillin-Resistant Staphylococcus aureus (MRSA). VCM MIC values in 49 MRSA strains were determined using VITEK2, Etest and broth microdilution method by dry plate 'Eiken' (DP). MIC50 and MIC90 values by each method were 0.5 ug/ml and 1 ug/ml by VITEK2, 2 ug/ml and 2 ug/ml by Etest, 1 ug/ml and 1 ug/ml by DP, respectively. The unachieved rate of AUC24/MIC≥400 was 2.8% by VITEK2, 36.1% by Etest, and 11.1% by DP. DP best predicted the clinical outcome of the 28 patients who were diagnosed as MRSA infection by the Infection Control Doctor. It is necessary to be careful about the difference of the MIC values by each testing methods in the MRSA treatment with VCM. |
| Keywords |
MRSA, Vancomycin, MIC, AUC24/MIC |
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