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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Long-term Changes in Susceptibility of Urinary Isolates to Various Antimicrobials |
| Language |
J |
| AuthorList |
Takashi Ando1), Koji Yoshikawa2), Masaharu Izumo3), Taira Nakamura1), Miyako Yakabe1), Kazumi Sakamoto1), Masaki Abe1), Hiroshi Kiyota4), Kenichi Sugimoto1) |
| Affiliation |
1) Department of Central Clinical Laboratory, The Jikei University Katsushika Medical Center
2) Department of Infectious Disease and Infection Control, The Jikei University Katsushika Medical Center
3) Department of Pharmacy, The Jikei University Katsushika Medical Center
4) Department of Urology, The Jikei University Katsushika Medical Center |
| Publication |
J.J.C.M.: 25 (4), 290-296, 2015 |
| Received |
March 4, 2015 |
| Accepted |
May 30, 2015 |
| Abstract |
The objective of this study is to investigate long-term changes in antimicrobial susceptibility to the major bacterial strains that cause urinary tract infections. Of the five major causal bacterial strains that were isolated from the samples derived from the urine at our hospital between 2007 and 2013, the strains that were examined by antimicrobial susceptibility testing were selected as the subjects. The susceptibility rate of Escherichia coli (2,389 strains) to levofloxacin was decreased from 80.7% to 73.3% over the seven-year period, and the susceptibility rates of E. coli to penicillin and cephem antibiotics were also declined. The susceptibility rate of Klebsiella pneumoniae (453 strains) to piperacillin was significantly decreased from 75.0% to 51.5%. On the other hand, the susceptibility rate of Pseudomonas aeruginosa (741 strains) showed an improving trend to various antimicrobials including quinolone antibiotics. Enterococcus faecalis (1,176 strains) and Streptococcus agalactiae (282 strains) maintained high susceptibility rates to penicillin and glycopeptide antibiotics throughout the study period. Of the tested isolates, E. coli showed a decrease in the susceptibility rates to the antimicrobials that have been recommended as empiric therapy, and K. pneumoniae showed a significant decrease in the susceptibility rate to piperacillin. The susceptibility of the other bacterial strains generally indicated favorable results. |
| Keywords |
piperacillin, extended-spectrum β-lactamase（ESBL） |
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