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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
| ArticleTitle |
Small colony variants of Staphylococcus aureus |
| Language |
J |
| AuthorList |
Takehisa Matsumoto, Kazuki Horiuchi, Tatsuya Negishi |
| Affiliation |
Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan |
| Publication |
J.J.C.M.: 26 (1), 1-10, 2015 |
| Received |
October 29, 2015 |
| Accepted |
|
| Abstract |
Bacterial variants of Staphylococcus aureus called small colony variants (SCVs) originate by mutations in metabolic genes, resulting in emergence of auxotrophic bacterial subpopulations. SCVs are resistant to various antibiotics such as aminoglycosides, trimethoprim-sulfamethoxazole, fluorquinolones, fusidic acid or triclosan. In late years, causative mechanisms for hemin, menadione and thymidine-dependent SCVs have been revealed. Clinically, small colony variants are better able to persist in mammalian cells and are less susceptible to antibiotics than their wild-type counterparts, and can cause latent or recurrent infections on emergence from the protective environment of the host cell. This review covers the auxotrophy, genetic mechanisms and clinical laboratory tests for S. aureus SCVs. |
| Keywords |
Staphylococcus aureus, Small-colony variants |
|
