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The Journal of the Japanese Society for Clinical Microbiology |
Biblioraphy Information
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[Vol.27 No.3 contents] Japanese / English |
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| ArticleTitle | A nosocomial outbreak caused by IMP-1 metallo-β-lactamase-producing Enterobacteriaceae of multiple species by plasmid-mediated horizontal gene transfer |
| Language | J |
| AuthorList | Tomoko Abe1), Yumi Nagata2), Mari Matsui3), Tomonobu Aoki2), Keigo Shibayama3), Tsuyoshi Sekizuka4), Akifumi Yamashita4), Hisashi Horiuchi5), Yoshiko Yamaguchi6), Mari Watanabe1), Eiko Okuma1), Makoto Kuroda4), Satowa Suzuki3) |
| Affiliation |
1) Department of Clinical Laboratory, Fukuoka Children's Hospital 2) Infection Control Office, Fukuoka Children's Hospital 3) Department of Bacteriology II, National Institute of Infectious Diseases 4) Pathogen Genomics Center, National Institute of Infectious Diseases 5) Department of Clinical Laboratory, Fukuoka City Hospital 6) Department of Pharmacy, Fukuoka Children's Hospital |
| Publication | J.J.C.M.: 27 (3), 158-167, 2017 |
| Received | September 16, 2016 |
| Accepted | March 17, 2017 |
| Abstract | We report a nosocomial outbreak caused by metallo-β-lactamase (MBL)-producing Enterobacteriaceae (MPE) of multiple species. Because the first case A was hospitalized in the intensive care unit (ICU) for 16 months prior to the isolation of imipenem-resistant MBL-producing Enterobacter aerogenes from a urine sample, nosocomial transmission of the MBL producer within the ICU was suspected. Active surveillance to detect other colonized cases was conducted in the ward associated with case A. As a result, 23 MPE isolates of seven species in five genera of Enterobacteriaceae were obtained from 15 patients, including the first case A. Environmental investigation also detected MPE isolates from a brush used to wash injection-related devices. All 23 isolates were positive for the IMP-1-type MBL genes, and eight isolates of different species shared almost identical plasmids. Nosocomial outbreaks of antimicrobial-resistant bacteria are usually caused by clones of a single species. However, in this outbreak, the MPE isolates belonged to seven different species that shared almost identical plasmids harboring the IMP-1-type MBL gene. Accordingly, we conclude that plasmid-mediated horizontal gene transfer of the IMP-1-type MBL gene was involved in this outbreak. Given that plasmid-mediated horizontal transfer of the MBL gene is known to occur among Enterobacteriaceae, it is important to consider the possibility of nosocomial outbreak even when isolates in an outbreak belong to different bacterial species. |
| Keywords | IMP-1 |
| Copyright © 2002 The Japanese Society for Clinical Microbiology All rights reserved. |