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Vol.34 No.5 contents | Japanese/English |
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Full Text of PDF (339K) Article in Japanese |
Antibiotic Prophylaxis to Prevent Infective Endocarditis before Dental Treatment
Akira UKIMURA1)2)
1)Infection control center, Osaka medical college Hospital, 2)Department of third internal medicine, Osaka Medical College
Infective endocarditis (IE) is a rare infectious disease, affecting approximately 5-10 people per 100,000 people per annum. Antibiotic prophylaxis for IE before dental treatment has been recommended for patients with predisposing cardiac conditions since 1950s because IE is associated with a high mortality and morbidity. However, the recommendations were partially or totally abandoned in 1990s in the US and Europe because the effectiveness of such antibiotic prophylaxis was not proved in these nations. The revised guidelines by the Japanese Circulation Society in 2017 recommend antibiotic prophylaxis both for highest risk and moderate-risk patients. This article outlines the history of antibiotic prophylaxis and reviews the evidence base for the use of antibiotic prophylaxis to prevent IE.
Key words：infective endocarditis, dental treatment, antibiotic prophylaxis
e-mail: in3011＠osaka-med.ac.jp
Received: June 3, 2019
Accepted: June 17, 2019
34 (5)：237─241,2019
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