Japanese Society for Infection Prevention and Control-Online Journal

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Article in Japanese

Relationship between the Adverse Reactions after the Second and Third Doses of the BNT162b2 Vaccine

Yuta SASAKI and Masamichi AMASAKI
Department of Pharmacy, Yamaguchi Red Cross Hospital

The third dose of COVID-19 vaccine has been administered in Japan since December 2021. In this study, we conducted a questionnaire survey on 539 employees of the Yamaguchi Red Cross Hospital regarding adverse reactions after the second and third doses of the vaccine. The results of the questionnaire survey indicated that fever (37.5°C or higher), fatigue, headache, chills, vomiting/nausea, diarrhea, myalgia, and joint pain) and local reactions (pain, redness, swelling, induration, scratchiness, and heat at the injection site) were significantly more likely to occur after the second dose and then after the third dose when adverse reactions were present. Based on adverse reactions after the second immunization, we believe that the occurrence of adverse reactions after the third immunization can be predicted.

Key words：BNT162b2 Vaciine, mRNA vaccine, side effect

e-mail: yrc-y＠c-able.ne.jp

Received: March 15, 2022
Accepted: August 17, 2022

38 (1)：22─25,2023