 |
 |
Search | |
Vol.34 No.2 contents | Japanese/English |
 |
Full Text of PDF (328K) Article in Japanese |
Feasibility and Value of Developing an Age-stratified Antibiogram
Yoshihiro NISHITA1)2), Masatoshi TAGA1)2), Yasuhiro KAWAI2)3), Yoko NODA2), Yoshiko NAKAGAWA2), Yoshitsugu IINUMA2)3) and Osamu NIWA1)
1)Department of Pharmacy, Kanazawa Medical University Hospital, 2)Department of Infection Control and Prevention, Kanazawa Medical University Hospital, 3)Department of Infectious Disease, Kanazawa Medical University
The aim of the current study was to investigate the significance of an age-stratified antibiogram. We compared the antimicrobial susceptibility rates of the most common bacteria isolated from children, non-elderly adults, and elderly adults in our hospital between April 2015 and March 2016: Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Escherichia coli, and Pseudomonas aeruginosa.
In gram-positive bacteria, the bacteria isolated from children showed significant differences compared to those from the adult groups as follows: methicillin-sensitive S. aureus showed lower sensitivity to macrolides; methicillin-resistant S. aureus showed higher sensitivities to levofloxacin (LVFX) and minocycline; and S. pneumoniae showed lower sensitivity to penicillin G with the meningitis criteria. No significant differences were observed between the non-elderly and elderly groups. In gram-negative bacteria, the bacteria isolated from children and elderly adults showed relatively lower sensitivities than those from non-elderly adults. In particular, E. coli showed lower sensitivities to multiple kinds of drugs, including ampicillin/sulbactam, cephem antibiotics, LVFX, trimethoprim/sulfamethoxazole, and fosfomycin. The isolation rate of drug-resistant bacteria was the lowest in the non-elderly group, which implies the necessity for care and attention in empiric therapy for children and the elderly. Our results suggested that developing an age-stratified antibiogram would be useful in treating infectious diseases, especially in empiric therapy for children and elderly adults.
Key words：empiric therapy, antibiogram, age-stratification
e-mail: yoshi-n＠kanazawa-med.ac.jp
Received: September 11, 2018
Accepted: December 17, 2018
34 (2)：115─121,2019
 |
| Copyright © 2003 Japanese Society for Infection Prevention and Control All rights reserved. |