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Vol.35 No.5 contents | Japanese/English |
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Full Text of PDF (307K) Article in Japanese |
Impact of Pharmacist Initiated Antimicrobial Stewardship Program～Evaluation of Antimicrobial Resistance Rate at Three Years after Intervention～
Yasuhiro SASAKI1)7), Akira KURISHIMA2), Misato AMANO1)7), Ayumi KANAMARU3)7), Akiko YAMAKUCHI4)7), Hirobumi TAKAYASU5)7) and Masataka YANO6)7)
1)Department of Pharmacy, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 2)Department of Pharmacy, Japan Community Health Care Organization Tokyo Shinjuku Medical Center, 3)Department of Nursing, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 4)Department of Microbiological Laboratory, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 5)Department of Pediatrics, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 6)Department of Urology, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation, 7)Antimicrobial Stewardship Team, Tama-Nanbu Chiiki Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation
In Tama-Nanbu Chiiki Hospital, a pharmacist-initiated antimicrobial stewardship program was started to optimize the use of antimicrobial agents in the hospital. Previously, at 10 months after the start of the program, the therapy durations for both 4th cephem and carbapenem were shortened. However, at that time, the resistance rate of Pseudomonas aeruginosa for both agents did not markedly change. Currently, we evaluated the correlation between the resistance rate of Pseudomonas aeruginosa and above mentioned antibiotics at 3 years after intervention. Although the day of therapy (DOT) was almost the same as that at 10 months of intervention, we achieved decreased resistance of Pseudomonas aeruginosa for both antibiotics. A positive correlation was observed between 4th cephem resistance rate in Pseudomonas aeruginosa and DOT (0.90, p = 0.04).
To reduce the antimicrobial resistance rate, a longer period of intervention is recommended.
Key words：antimicrobial stewardship, Pseudomonas aeruginosa, Antimicrobial resistance
e-mail: yasuhiro_sasaki1＠tokyo-hmt.jp
Received: April 8, 2020
Accepted: June 9, 2020
35 (5)：201─205,2020
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