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Vol.33 No.2 contents | Japanese/English |
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Full Text of PDF (253K) Article in Japanese |
The Minimum Killing Concentrations of Chlorhexidine Gluconate and Olanexidine Gluconate on Clinically Isolated S.aureus Strains
Yasushi NAKAZAWA1)2), Taku TAMURA1) and Seiji HORI2)
1)Department of Infection Control, Jikei University Hospital, 2)Department of Infectious Disease and Infection Control, Jikei University School of Medicine
We investigated the minimum killing concentrations of chlorhexidine gluconate (CHG) and olanexidine gluconate (OLN) on clinically isolated Staphylococcus aureus strains. The concentration of CHG that inhibited growth of 50% of S. aureus strains (MKC50) was 0.1250%; the concentration that inhibited growth of 90% strain (MKC90) was 0.5000%. For OLN, MKC50 was 0.0020% and MKC90 was 0.0156%. Of the 137 strains, 18 strains (13.7%) had the qacA/B gene, the increase in MKC by holdings qacA/B was not observed. OLN showed bactericidal effect at low concentration compared with CHG.
Key words：chlorhexidine, olanexidine, MRSA, MSSA
e-mail: ynakazawa＠jikei.ac.jp
Received: May 16, 2017
Accepted: October 24, 2017
33 (2)：52─55,2018
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