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Vol.33 No.3 contents | Japanese/English |
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Full Text of PDF (322K) Article in Japanese |
A Study of Persistence of Anti-HBs Antibodies after Vaccination with Recombinant Hepatitis B Vaccine in Healthcare Workers
Sumio IWASAKI1)2), Reiko OYAMADA2), Tsubasa WATANABE2), Kiyomi HASUIKE3), Sumito NAKAMURA2), Takehiro YAMADA2)4), Koji OBA5) and Nobuhisa ISHIGURO2)
1)Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, 2)Infection Control Center, Hokkaido University Hospital, 3)Division of Hospital Safety Management, Hokkaido University Hospital, 4)Division of Pharmacy, Hokkaido University Hospital, 5)Department of Biostatistics, School of Public Health, Graduate School of Medicine, The University of Tokyo
A total of 237 healthcare workers who had successfully acquired protective levels of anti-HBs antibodies (≥10 mIU/mL) by recombinant hepatitis B vaccine were followed up for a period of five years. Only 2.0% of the vaccinees who had acquired anti-HBs antibody levels of 10-49 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later, and only 16.7% of the vaccinees who had acquired anti-HBs antibody levels of 50-99 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later. On the other hand, 87.0% of the vaccinees who had acquired anti-HBs antibody levels of ≥400 mIU/mL four months after the third dose of vaccine had anti-HBs antibody levels higher than 10 mIU/mL five years later. Persistence of anti-HBs antibodies depends on the anti-HBs titer at four months after the third dose of recombinant hepatitis B vaccine.
Key words：recombinant hepatitis B vaccine, anti-HBs antibody, persistence of antibody
e-mail: sumio55＠med.hokudai.ac.jp
Received: August 23, 2017
Accepted: March 6, 2018
33 (3)：117─122,2018
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