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Survey of Antimicrobial Prophylaxis Agents and Surgical Site Infection Status Regarding Teeth Extraction in a Dental Outpatient Clinic

Kensuke YOSHIDA1)2), Yasumitsu KODAMA1), Hirokazu ISOBE2)3), Eiko YAMADA1), Atsushi NISHIKAWA1) and Ritsuo TAKAGI1)
1)Division of Oral and Maxillofacial Surgery, Niigata University Graduate School of Medical and Dental Sciences, 2)Division of Hospital Pharmacy, Niigata University Medical and Dental Hospital, 3)Division of Infection Control and Prevention, Niigata University Medical and Dental Hospital


Antimicrobial resistance has been a problem worldwide and because of this, each medical institution is required to gather evidence of antimicrobial agent usage and its compatibility with the bacteria. Although the dental ward at the Niigata University Medical and Dental Hospital are advancing in antimicrobial management, antimicrobial prophylactic oral agents in the dental outpatient clinic was left to the discretion of the dentists. However, there are other unanswered questions. Therefore, the aim of this study was to evaluate the management of the antimicrobial agents' usage review and surgical site infection (SSI) status for the dental outpatient clinic from the perspective of a pharmacist. During January 2012-December 2016), we retrospectively analyzed the simple extraction of permanent tooth with the presence or absence of antimicrobial prophylactic agent, type, dosage, and SSI. We found that antimicrobial prophylactic agents were administered in approximately 70% of the patients in the dental outpatient clinic for an average of 3 days, 80% of which used third-generation cephalosporins. On the other hand, there was no significant difference in SSI with regard to the presence or absence of antimicrobial prophylactic agents. Therefore, antimicrobial prophylactic agents may not affect the SSI after a simple tooth extraction. According to the guideline, antimicrobial prophylactic agents are not recommended for simple tooth extraction and the first choice of antimicrobial prophylactic agents are penicillin; therefore, we have to advance antimicrobial management in our dental outpatient clinic.

Key words:simple tooth extraction, antimicrobial prophylactic agent, antimicrobial management, surgical site infection (SSI), dental outpatient clinic

e-mail: kensukeyoshida-nii@umin.ac.jp

Received: February 21, 2018
Accepted: May 22, 2018

33 (5):207─212,2018

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