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The Japanese journal of neuropsychology
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Full Text of this Article
in Japanese PDF (278K)
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ArticleTitle
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What types of cognitive dysfunction correlate with the functional impairment in Alzheimer's disease: Stratified analyses according to overall cognitive severity |
Language |
J |
AuthorList |
Yukino Suzuki1), Azusa Kato1), Takuya Sato2), Toru Imamura1)3) |
Affiliation |
1)Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare
2)Division of Speech Therapy, Department of Rehabilitation, Niigata Rehabilitation Hospital
3)Department of Neurology, Niigata Rehabilitation Hospital |
Publication |
Japanese Journal of Neuropsychology: 34 (3), 235-241, 2018 |
Received |
Oct 23, 2017 |
Accepted |
Jun 11, 2018 |
Abstract |
We investigated the relation between the functional impairment and different types of cognitive dysfunction in patients with Alzheimer's disease (AD). We stratified the patients according to overall cognitive severity, that is, 232 AD patients with a Mini-Mental State Examination (MMSE) score of 15 to 26 were classified into 4 groups, and evaluated correlations between the Sum of Boxes in Clinical Dementia Rating (CDR-SOB) and the indices of different cognitive dysfunction in each patient group. The CDR-SOB correlated with the score of the backward digit span task in the group with MMSE scores of 15 to 17, the score of the recent memory task in the group with MMSE scores of 18 to 20, and the score of the orientation task in the group with MMSE scores of 24 to 26. Different types of cognitive dysfunction strongly affect functional impairment in patients with different severities of overall cognitive dysfunction, because patients with different cognitive severities have differently preserved amounts of community, home and self-care affairs. |
Keywords |
Alzheimer's disease, functional status, cognitive dysfunction, clinical dementia rating (CDR) |
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