The Japanese journal of neuropsychology

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ArticleTitle	The clinical features of logopenic progressive aphasia (2020 version)
Language	J
AuthorList	Nanayo Ogawa¹⁾²⁾, Shigenori Kanno¹⁾, Wataru Narita¹⁾³⁾, Kyoko Suzuki¹⁾
Affiliation	¹⁾Department of Behavioral Neurology and Cognitive Neuroscience, Tohoku University Graduate School of Medicine ²⁾Department of Rehabilitation, Kasugai Municipal Hospital ³⁾Department of Rehabilitation, Sendai Rehabilitation Hospital
Publication	Japanese Journal of Neuropsychology: 37 (3), 152-163, 2021
Received
Accepted
Abstract	More than 10 years have passed since the clinical diagnosis of logopenic progressive aphasia (LPA) was proposed as the third type of primary progressive aphasia (PPA). During this period, over 400 studies on LPA have been published in English. However, the concept of LPA remains ambiguous because its core symptoms such as word-finding difficulty and impaired repetition, are also observed in other types of PPA. We reviewed 33 cases with LPA who were native Japanese speakers. In addition to the aforementioned core features, they sometimes showed impaired repetition of long words or difficulty in comprehending sentences or words. Meanwhile, five cases had no logopenia or seven cases showed no phonetic paraphasia in spontaneous speech. Although autopsy data revealed Alzheimer's disease as the most common pathologic diagnosis in LPA, other pathologies have been reported including, frontotemporal lobar degeneration with TDP-43 and tau-positive inclusions and dementia with Lewy bodies (DLB). LPA symptoms due to DLB pathology may be improved with donepezil. The consensus criteria for PPA did not capture all the language profiles of patients with PPA, resulting in unclassifiable or mixed phenotypes. Further investigations through clinical, structural, and functional imaging are needed to improve the accuracy of the diagnosis and identification of the underlying etiology in PPA.
Keywords	primary progressive aphasia (PPA), logopenic progressive aphasia (LPA), repetition, Alzheimer disease (AD), dementia with Lewy bodies (DLB)