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[Vol.37 No.3 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (1706K) |
| ArticleTitle | Semantic dementia with impaired repetition of sentences and phrases due to Alzheimer's disease pathology: A linkage between neuropsychology and brain imaging in neurodegenerative diseases |
| Language | J |
| AuthorList | Shinobu Kawakatsu1), Ryota Kobayashi2), Hiroshi Hayashi2), Daichi Morioka2), Koichi Otani2) |
| Affiliation |
1)Department of Neuropsychiatry, Aizu Medical Center, Fukushima Medical University 2)Department of Psychiatry, Yamagata University School of Medicine |
| Publication | Japanese Journal of Neuropsychology: 37 (3), 201-211, 2021 |
| Received | |
| Accepted | |
| Abstract | To illustrate a linkage between neuropsychology and brain imaging in neurodegenerative diseases, we presented a patient with sematic dementia accompanying repetition of sentences due to Alzheimer's disease pathology. A right-handed man in his 60s complained of progressive word finding difficulties for 6 years. On examination, moderated impairment in naming and comprehension was noted. Repetition was also impaired with phonological paraphasia. However, he continued to do his job with preserved episodic memory. MRI revealed moderate atrophy of the left anterior temporal lobe and SPECT depicted marked hypoperfusion in the left anterior temporal and parietal regions. Over the course of seven years, his language symptoms progressed to mutism with generalized dementia, and he died of pneumonia. Neurofibrillary tangles and neuropil threads were abundant throughout the cerebral cortex, particularly in the left anterior temporal and mid/inferior temporal cortex, while these were less prominent in the left posterior part of the superior temporal cortex and temporoparietal junction, the lesion relating to logopenic primary progressive aphasia. This case was an atypical AD presenting semantic dementia who had tau pathology distribution accentuated in the left anterior temporal lobe. |
| Keywords | semantic dementia, logopenic variant, Alzheimer's disease, impaired repetition of sentences |
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