The Japanese journal of neuropsychology

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ArticleTitle	Late-onset psychosis and tauopathies
Language	J
AuthorList	Osamu Yokota¹⁾²⁾, Tomoko Miki¹⁾²⁾, Takashi Haraguchi³⁾, Chikako Ikeda⁴⁾, Hideki Ishizu⁴⁾, Seishi Terada²⁾, Norihito Yamada²⁾
Affiliation	¹⁾Department of Psychiatry, Kinoko Espoir Hospital ²⁾Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences ³⁾Department of Neurology, National Hospital Organization Minami-Okayama Medical Center ⁴⁾Department of Psychiatry, Zikei Institute of Psychiatry
Publication	Japanese Journal of Neuropsychology: 38 (2), 109-119, 2022
Received
Accepted
Abstract	Several previous studies supported the potential relationship between the development of late-onset psychosis and several tauopathies, i.e., argyrophilic grain disease (AGD), senile dementia of the neurofibrillary tangle type (SD-NFT), and progressive supranuclear palsy (PSP). It was reported that AGD may be associated with the development of late-onset psychosis, as well as the development of late-onset bipolar disorder, the severity of post-stroke depression, and the socioeconomic status. Tau accumulation in the nucleus accumbens in SD-NFT cases was significantly more severe than that in Braak stage-matched Alzheimer's disease cases, and SD-NFT cases are known to often show delusion in life. Severe tau accumulation in the nucleus accumbens was also associated with delusion in cases of Alzheimer's disease. It was reported that 4.8% of patients with PSP showed delusion within three years after the onset. The development of surrogate markers for molecular pathologies, as well as the accumulation of clinicopathological findings, may be necessary for better understanding of the pathogenic background of psychosis that occurs in middle-to-late life.
Keywords	argyrophilic grain disease, progressive supranuclear palsy, four-repeat tauopathy, psychosis, senile dementia of the neurofibrillary tangle type