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[Vol.39 No.1 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (1324K) |
| ArticleTitle | Rewiring of corticospinal tract after central nervous system injuries |
| Language | J |
| AuthorList | Takahiro Inoue, Masaki Ueno |
| Affiliation | Department of System Pathology for Neurological Disorders, Brain Research Institute, Niigata University |
| Publication | Japanese Journal of Neuropsychology: 39 (1), 30-39, 2023 |
| Received | |
| Accepted | |
| Abstract | Corticospinal tract (CST) is an essential neural pathway for voluntary and skilled movements, which is often damaged by the central nervous system (CNS) injuries such as stroke and spinal cord injury, imposing severe motor impairments in patients. There are no reliable treatments so far to achieve complete recovery, which is especially attributed to limited capacity of CNS to reconstruct the neural circuits. Recent studies including ours have highlighted that the spared CST axons are dynamically reorganized and contribute to recovery after CNS injuries. Here, we review the structures, functions, and basic principles of rewiring of the CST, which occurs in variable patterns in different injury site and size, and describe potential therapeutic approaches to promote CST rewiring and recovery after CNS injuries. |
| Keywords | corticospinal tract, rewiring, sprouting, stroke, spinal cord injury |
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