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[Vol.40 No.2 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (664K) |
| ArticleTitle | Lesion-symptom associations in focal brain lesions and neurodegenerative disorders: A focus on language impairments |
| Language | J |
| AuthorList | Yuichi Higashiyama, Fumiaki Tanaka |
| Affiliation | Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine |
| Publication | Japanese Journal of Neuropsychology: 40 (2), 115-125, 2024 |
| Received | |
| Accepted | |
| Abstract | In neuropsychology, symptomatology has traditionally developed through the study of lesion localization and symptom mapping, mainly in patients with focal brain lesions. Since the 1980s, however, primary progressive aphasia (PPA) caused by neurodegenerative disorders has regained attention and numerous studies are currently underway. At the same time, neuroimaging research has shown that language functions as a complex network involving various cortical areas and white matter fibers. Against this background, recent research on lesion-symptom associations has entered new phases, using techniques such as disconnectome analysis and longitudinal analyses with linear mixed-effects models. On the other hand, there are notable differences in the quality and frequency of symptoms between focal brain lesions and neurodegenerative disorders. These differences may be due to differences in the spatial distribution of lesions, temporal progression, and resulting patterns of functional compensation. |
| Keywords | aphasia, stroke aphasia, primary progressive aphasia, disconnectome |
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