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[Vol.31 No.2 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (496K) |
| ArticleTitle | Neuropsychological symptom in Parkinson's disease and its relation to dopaminergic and acetylcholinergic degeneration |
| Language | J |
| AuthorList | Hiroyasu Tanaka, Atsushi Takeda |
| Affiliation | Department of Neurology, National Hospital Organization Sendai Nishitaga Hospital |
| Publication | Japanese Journal of Neuropsychology: 31 (2), 99-107, 2015 |
| Received | |
| Accepted | |
| Abstract | In the brain of Parkinson's disease (PD), degenerative processes are known to involve not only dopaminergic neurons, but also other neuronal systems including cholinergic neurons, and such pathophysiological changes are closely associated with cardinal motor symptoms and various non-motor features. Hyposmia is one of the most common non-motor symptoms in PD, even from the prodromal stages. Moreover, severe hyposmia was recently identified as the important predictor of dementia in PD. Addition to the traditional dopamine replacement therapy, the cholinergic enhancement may hopefully be a new treatment strategy to improve the prognosis of PD. |
| Keywords | Parkinson's disease, dopamine, acetylcholine, olfaction, dementia |
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