The Japanese journal of neuropsychology

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ArticleTitle	What types of cognitive dysfunction correlate with the functional impairment in Alzheimer's disease: Stratified analyses according to overall cognitive severity
Language	J
AuthorList	Yukino Suzuki¹⁾, Azusa Kato¹⁾, Takuya Sato²⁾, Toru Imamura¹⁾³⁾
Affiliation	¹⁾Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare ²⁾Division of Speech Therapy, Department of Rehabilitation, Niigata Rehabilitation Hospital ³⁾Department of Neurology, Niigata Rehabilitation Hospital
Publication	Japanese Journal of Neuropsychology: 34 (3), 235-241, 2018
Received	Oct 23, 2017
Accepted	Jun 11, 2018
Abstract	We investigated the relation between the functional impairment and different types of cognitive dysfunction in patients with Alzheimer's disease (AD). We stratified the patients according to overall cognitive severity, that is, 232 AD patients with a Mini-Mental State Examination (MMSE) score of 15 to 26 were classified into 4 groups, and evaluated correlations between the Sum of Boxes in Clinical Dementia Rating (CDR-SOB) and the indices of different cognitive dysfunction in each patient group. The CDR-SOB correlated with the score of the backward digit span task in the group with MMSE scores of 15 to 17, the score of the recent memory task in the group with MMSE scores of 18 to 20, and the score of the orientation task in the group with MMSE scores of 24 to 26. Different types of cognitive dysfunction strongly affect functional impairment in patients with different severities of overall cognitive dysfunction, because patients with different cognitive severities have differently preserved amounts of community, home and self-care affairs.
Keywords	Alzheimer's disease, functional status, cognitive dysfunction, clinical dementia rating (CDR)