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[Vol.35 No.2 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (329K) |
| ArticleTitle | Near type of closing-in phenomenon in Alzheimer's disease |
| Language | J |
| AuthorList | Mizuho Murata1), Azusa Kato1)2), Takuya Sato3), Atsushi Sato3), Toru Imamura1)2) |
| Affiliation |
1)Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare 2)Department of Neurology, Niigata Rehabilitation Hospital 3)Division of Speech Therapy, Department of Rehabilitation, Niigata Rehabilitation Hospital |
| Publication | Japanese Journal of Neuropsychology: 35 (2), 109-116, 2019 |
| Received | Aug 28, 2018 |
| Accepted | Mar 5, 2019 |
| Abstract | Backgrounds: Closing-in phenomenon was classified into 4 types, that is, adherent or overlapping, involving, tracing, and near types. Previous studies suggested the relations between the types of closing-in phenomenon and cognitive deficits as follows; (a) adherent or overlapping type and executive dysfunction, (b) involving type and visuocognitive disturbances and (c) tracing type and forced grasping. Objective: To examine the relation between near-type closing-in phenomenon and demographic, disease and cognitive factors. Subjects: 40 healthy elderly volunteers and 240 patients with Alzheimer's disease (AD) who presented to our memory clinic. Methods: We defined the near-type closing-in phenomenon in the Construction subtest of Alzheimer's Disease Assessment Scale (ADAS) based on the data from the healthy elderly subjects. Logistic regression analyses investigated the factors predicting the presence of near-type closing-in phenomenon in the AD patients. Results: Worse scores of the Mini-Mental State Examination (MMSE) significantly predicted the presence of near-type closing-in phenomenon. After excluding the effect of MMSE score, the incidence of near-type closing-in phenomenon showed a significant increase with a worse performance on the Ideational Praxis subtest of ADAS. Conclusion: The results suggested the relation between the near type of closing-in phenomenon and executive dysfunction in AD, after excluding the effect of the overall severity of cognitive impairment. |
| Keywords | closing-in phenomenon, Alzheimer's disease, constructional disturbance, executive dysfunction |
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