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The Japanese journal of neuropsychology
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Full Text of this Article
in Japanese PDF (255K)
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ArticleTitle
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Paradigm shift in diagnostic approach to Alzheimer's disease by use of biomarkers |
Language |
J |
AuthorList |
Takeshi Ikeuchi |
Affiliation |
Brain Research Institute, Niigata University |
Publication |
Japanese Journal of Neuropsychology: 36 (1), 20-24, 2020 |
Received |
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Accepted |
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Abstract |
Diagnostic criteria for Alzheimer's disease (AD) has been established mainly based on the clinical features and the exclusion of other types of dementia. New technologies such as biomarkers and molecular imaging have enabled to estimate the pathological changes occurring in patients with AD. Thus, combination of clinical symptoms and biomarker findings have been incorporated into recent diagnostic criteria provided by NIA-AA (2011) and IWG-2 working groups (2014). Recently, research framework criteria (2018) was proposed to understand AD predominantly from the viewpoint of biomarker changes independently from the clinical status. Here, a paradigm shift in diagnostic approach to AD emerged by use of biomarkers is discussed. |
Keywords |
Alzheimer's disease, biomarker, diagnostic criteria, blood-based marker |
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