The Japanese journal of neuropsychology

Full Text of this Article
in Japanese PDF (40K)

ArticleTitle	Distinctive features of cognitive impairment in corticobasal degeneration demonstrated by Alzheimer's Disease Assessment Scale -Comparison with Alzheimer's disease and progressive supranuclear palsy-
Language	J
AuthorList	Kaori Kitada, Nobutsugu Hirono, Chihiro Hasegawa, Etsuro Mori
Affiliation	Division of Clinical Neurosciences, Hyogo Institute for Aging Brain and Cognitive Disorders
Publication	Japanese Journal of Neuropsychology: 18 (1), 53-59, 2002
Received	Aug 3, 2001
Accepted	Oct 22, 2001
Abstract	In order to detect the distinctive features of cognitive impairment in corticobasal degeneration (CBD), 21 consecutive patients with a clinical diagnosis of CBD were compared with 247 with probable Alzheimer's disease (AD) and 17 with progressive supranuclear palsy (PSP), who are between 51 and 75 years old and achieved 11 or more scores of the Mini-Mental State Examination (MMSE), by using a Japanese version of the Alzheimer's Disease Assessment Scale-Cognitive part (ADAS-J Cog.). All three groups are comparable with MMSE score and total score of ADAS-J Cog., however, the AD group was significantly older and consisted of larger proportion of female patients than the other two patients groups. The mean scores of the Following Commands, Constructional Praxis, and Ideational Praxis subtests were significantly lower in the CBD group than in the AD and PSP groups. On the contrary, the mean score of the Orientation subtest was significantly higher in the CBD group than in the CBD and PSP groups. There was no significant difference in the mean score of the Word Recognition subtest among the three groups. However, when false alarms were taken into consideration by calculating the mean of hits and correct rejections instead of the number of correct answer, the modified score of the Word Recognition subtest was significantly higher in the CBD group than in the AD group. These results demonstrated that CBD patients have distinctive features of cognitive impairment, and that ADAS-J Cog. is a helpful tool to detect them.
Keywords	coritcobasal degeneration, Alzheimer's disease, progressive supranuclear palsy, Alzheimer's Disease Assessment Scale (ADAS), cognitive function