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[Vol.22 No.3 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (283K) |
| ArticleTitle | Aphasia in Pick's disease with Pick bodies: the responsible lesion in two autopsy cases presenting with apraxia of speech as the initial sign and literature review |
| Language | J |
| AuthorList | Kuniaki Tsuchiya1), Osamu Yokota2) |
| Affiliation |
1) Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Matsuzawa Hospital 2) Department of Neuropathology, Tokyo Institute of Psychiatry |
| Publication | Japanese Journal of Neuropsychology: 22 (3), 178-192, 2006 |
| Received | |
| Accepted | |
| Abstract | We report the clinicopathological features of two autopsy cases of Pick's disease with Pick bodies presenting with apraxia of speech as an initial sign. We examined the responsible lesion for apraxia of speech using hemisphere and bisphere specimens, respectively. Cerebral cortical lesions was divided into three categories (slight, moderate, and severe). We elucidated severe lesions in the posterior portion of the left inferior frontal gyrus (pars opercularis) in the two autopsy cases. In contrast, the precentral lesions of the two cases were relatively moderate. Literature review concerning ten autopsy cases, including our two cases, showing the aphasia as the initial sign, disclosed that in eight cases of ten cases "motor aphasia" was the initial sign. |
| Keywords | Pick's disease, Pick body, ballooned neuron, aphasia, responsible lesion |
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