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[Vol.23 No.2 contents]
Japanese/English
Full Text of this Articlein Japanese PDF (980K) |
| ArticleTitle | A longitudinal study of primary progressive aphasia with conduction aphasia |
| Language | J |
| AuthorList | Miwako Ishimaru1)4), Junko Sanada2), Kenjiro Komori3), Manabu Ikeda3)5), Hirotaka Tanabe3) |
| Affiliation |
1) Psychology Section, Nanohana Clinic 2) Department of Psychiatry, Nanohana Clinic 3) Department of Neuropsychiatry, Neuroscience, Ehime University Graduate School of Medicine 4) Psychology Section, Mishima Hospital 5) Department of Psychiatry and Neuropathobiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University |
| Publication | Japanese Journal of Neuropsychology: 23 (2), 144-150, 2007 |
| Received | Mar 22, 2006 |
| Accepted | Oct 10, 2006 |
| Abstract |
We reported a case of progressive fluent aphasia associated with diffuse atrophy of the left hemisphere. A 64-year-old right-handed woman with 16 years of education presented with five-year history of slowly progressive anomia. At the initial assessment, MRI showed diffuse atrophy of the posterior part of the brain, more marked on the left side. HMPAO-SPECT demonstrated hypoperfusion of the left posterior temporo-parietal and inferior temporal regions. Naming performance on the one-year follow-up examination revealed her phonemic paraphasia with self-correction, which was a core feature of conduction aphasia. She could not reach the target words after several trials of self-correction after two-year follow-up. Then she also showed severe impairments in both reading and writing Kanji or Kana words, though Kanji writing was relatively preserved. Literal paragraphias and writing Kana errors in words with special syllables as a double consonant or a sonant mark were evident. Her day-to-day memory and ADL were still preserved while neuropsychological assessments revealed mild disturbances in non-verbal intelligence, short-term memory, calculation and visual memory. These clinical features fulfilled diagnostic criteria for primary progressive aphasia (PPA). In conclusion, the left temporo-parietal lesion in this patient could cause her progressive phonological disturbances. Detailed investigations for the variety of clinical features in PPA might be needed for accurate diagnosis and useful rehabilitation. |
| Keywords | primary progressive aphasia, amnesic aphasia, conduction aphasia, neuropsychological assessment, longitudinal study |
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