Journal

The Japanese journal of neuropsychology

[Vol.25 No.4 contents]
Japanese/English

Full Text of this Article
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ArticleTitle Short Fluctuations Questionnaire (SFQ): a structured interview for cognitive fluctuation in dementia with Lewy bodies (DLB)
Language J
AuthorList Atsuko Nagashima1), Chie Ichino2), Takuya Sato2), Atsushi Sato2), Toru Imamura1)3)
Affiliation 1)Department of Speech Therapy, School of Health Sciences, Niigata University of Health and Welfare
2)Division of Speech Therapy, Department of Rehabilitation, Niigata Rehabilitation Hospital
3)Department of Neurology, Niigata Rehabilitation Hospital
Publication Japanese Journal of Neuropsychology: 25 (4), 290-297, 2009
Received Feb 26, 2009
Accepted May 18, 2009
Abstract Objective: To assess the validity of the Short Fluctuations Questionnaire (SFQ); a new structured interview with 8 items for cognitive fluctuation in dementia with Lewy bodies (DLB). Subjects: 40 patients with a clinical diagnosis of Alzheimer's disease (AD), 18 patients with possible or probable DLB who showed visual hallucination, motor Parkinsonism or both. A behavioral neurologist, who was independent to the SFQ, classified each patient's cognitive fluctuation as "positive" or "negative". Methods: SFQ was administered to the reliable informant of each patient. The specificity or sensitivity of the 8-point score of the SFQ was evaluated in each patient group (DLB, AD, "positive" fluctuation and "negative" fluctuation). Results: The score of the SFQ with 3/4 cut-off points showed 61% sensitivity in DLB, 72% specificity in AD, 81% sensitivity in the patients with "positive" fluctuation, and 78% specificity in the patients with "negative" fluctuation. Conclusion: The score of the SFQ showed sufficient sensitivity and specificity to distinguished AD and DLB, and to predict the clinical diagnosis of "positive" or "negative" fluctuation. The SFQ may be useful to evaluate cognitive fluctuation in DLB.
Keywords Short Fluctuations Questionnaire, dementia with Lewy bodies: DLB, Alzheimer's disease: AD, Mayo Fluctuations Questionnaire, cognitive fluctutation

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